Some of this will depend on what you're selling. Are you selling digital products, physical products or both? I recommend finding two solutions: one for your e-commerce needs and one for your marketing needs. You will find the best options that way since there are very few platforms that offer e-commerce and big-picture marketing. Convertkit could be an all-in-one option if you are only selling digital. You could integrate Shopify, Woo Commerce, or your E-commerce platform of choice with Active Campaign, Klaviyo, Mailchimp, Constant Contact, or others.
Easy to learn and set up will depend on you and your experience with email marketing, web design, and marketing. Marketing is its own specialty, and these platforms will provide you with the tools and analytics, but it is up to you to create the strategies and how to use the data you need. Expect a learning curve and that you will need to do the work to see the results.